| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:10-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FMO3 |
| Gene ID: | 2328 |
| Uniprot ID: | FMO3_HUMAN |
| Immunogen Region: | 263-532 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 263-532 of human FMO3 (NP_001002294.1). |
| Immunogen Sequence: | RFKHENYGLMPLNGVLRKEP VFNDELPASILCGIVSVKPN VKEFTETSAIFEDGTIFEGI DCVIFATGYSFAYPFLDESI IKSRNNEIILFKGVFPPLLE KSTIAVIGFVQSLGAAIPTV DLQSRWAAQVIKGTCTLPSM EDMMNDINEKMEKKRKWFGK SETIQTDYIVYMDELSSFIG AKPNIPWLFLTDPKLAMEVY FGPCSPYQFRLVGPGQWPGA RNAILTQWDRSLKPMQTRV |
| Tissue Specificity | Liver. |
| Function | Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation. |
| Protein Name | Flavin-Containing Monooxygenase 3 Dimethylaniline Monooxygenase N-Oxide-Forming 3 Dimethylaniline Oxidase 3 Fmo Ii Fmo Form 2 Hepatic Flavin-Containing Monooxygenase 3 Fmo 3 Trimethylamine Monooxygenase |
| Database Links | Reactome: R-HSA-217271 Reactome: R-HSA-5579019 |
| Cellular Localisation | Microsome Membrane Single-Pass Membrane Protein Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Flavin-Containing Monooxygenase 3 antibody Anti-Dimethylaniline Monooxygenase N-Oxide-Forming 3 antibody Anti-Dimethylaniline Oxidase 3 antibody Anti-Fmo Ii antibody Anti-Fmo Form 2 antibody Anti-Hepatic Flavin-Containing Monooxygenase 3 antibody Anti-Fmo 3 antibody Anti-Trimethylamine Monooxygenase antibody Anti-FMO3 antibody |
Information sourced from Uniprot.org