| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FLVCR1 |
| Gene ID: |
28982 |
| Uniprot ID: |
FLVC1_HUMAN |
| Immunogen Region: |
250-350 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human FLVCR1 (NP_054772.1). |
| Immunogen Sequence: |
AVGFLLPPVLVPNTQNDTNL LACNISTMFYGTSAVATLLF ILTAIAFKEKPRYPPSQAQA ALQDSPPEEYSYKKSIRNLF KNIPFVLLLITYGIMTGAFY S |
| Tissue Specificity | Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney. |
| Post Translational Modifications | N-Glycosylated. |
| Function | Uniporter that mediates the transport of extracellular choline and ethanolamine into cells, thereby playing a key role in phospholipid biosynthesis. Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids. Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane. Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment. Isoform 1: Uniporter that mediates the transport of extracellular choline and ethanolamine into cells. Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids. Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane. Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythropoiesis, a process in which heme synthesis intensifies. Possibly export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. The molecular mechanism of heme transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated. Isoform 2: Heme b transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation. Isoform 1: (Microbial infection) Confers susceptibility to feline leukemia virus subgroup C (FeLV-C) infection in vitro. |
| Protein Name | Choline/Ethanolamine Transporter Flvcr1Feline Leukemia Virus Subgroup C Receptor-Related Protein 1Feline Leukemia Virus Subgroup C ReceptorHflvcrHeme Transporter Flvcr1 |
| Database Links | Reactome: R-HSA-189451Reactome: R-HSA-917937 Q9Y5Y0-1 |
| Cellular Localisation | Isoform 1: Cell MembraneMulti-Pass Membrane ProteinIsoform 2: Mitochondrion Membrane |
| Alternative Antibody Names | Anti-Choline/Ethanolamine Transporter Flvcr1 antibodyAnti-Feline Leukemia Virus Subgroup C Receptor-Related Protein 1 antibodyAnti-Feline Leukemia Virus Subgroup C Receptor antibodyAnti-Hflvcr antibodyAnti-Heme Transporter Flvcr1 antibodyAnti-FLVCR1 antibodyAnti-FLVCR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
