| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FLVCR1 (250-350) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FLVCR1 |
| Gene ID: |
28982 |
| Uniprot ID: |
FLVC1_HUMAN |
| Immunogen Region: |
250-350 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human FLVCR1 (NP_054772.1). |
| Immunogen Sequence: |
AVGFLLPPVLVPNTQNDTNL LACNISTMFYGTSAVATLLF ILTAIAFKEKPRYPPSQAQA ALQDSPPEEYSYKKSIRNLF KNIPFVLLLITYGIMTGAFY S |
| Tissue Specificity | Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney. |
| Post Translational Modifications | N-Glycosylated. |
| Function | Isoform 1: Heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythropoiesis, a process in which heme synthesis intensifies. Possibly export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. The molecular mechanism of heme transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated. Isoform 1: (Microbial infection) Confers susceptibility to feline leukemia virus subgroup C (FeLV-C) infection in vitro. Isoform 2: Heme b transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation. |
| Protein Name | Heme Transporter Flvcr1Feline Leukemia Virus Subgroup C Receptor-Related Protein 1Feline Leukemia Virus Subgroup C ReceptorHflvcr |
| Database Links | Reactome: R-HSA-189451Reactome: R-HSA-917937 Q9Y5Y0-1 |
| Cellular Localisation | Isoform 1: Cell MembraneMulti-Pass Membrane ProteinIsoform 2: Mitochondrion MembraneColocalizes With Hadha |
| Alternative Antibody Names | Anti-Heme Transporter Flvcr1 antibodyAnti-Feline Leukemia Virus Subgroup C Receptor-Related Protein 1 antibodyAnti-Feline Leukemia Virus Subgroup C Receptor antibodyAnti-Hflvcr antibodyAnti-FLVCR1 antibodyAnti-FLVCR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
