| Tissue Specificity | Expressed in brain, skeletal muscle, kidney, colon, adrenal gland, prostate, and placenta. Weakly or not expressed in heart, thymus, spleen, liver, small intestine, bone marrow, lung and peripheral blood leukocytes. Overexpressed in some colon and lung tumors. In skin, it is localized within the epidermis and particularly in basal keratocytes. Not detected in epidermal melanocytes and dermal fibroblasts. |
| Function | Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. |
| Protein Name | Fermitin Family Homolog 1KindlerinKindlin Syndrome ProteinKindlin-1Unc-112-Related Protein 1 |
| Cellular Localisation | CytoplasmCytoskeletonCell JunctionFocal AdhesionCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SideConstituent Of Focal AdhesionsLocalized At The Basal Aspect Of Skin KeratinocytesClose To The Cell MembraneColocalizes With Filamentous ActinUpon Tgfb1 TreatmentIt Localizes To Membrane Ruffles |
| Alternative Antibody Names | Anti-Fermitin Family Homolog 1 antibodyAnti-Kindlerin antibodyAnti-Kindlin Syndrome Protein antibodyAnti-Kindlin-1 antibodyAnti-Unc-112-Related Protein 1 antibodyAnti-FERMT1 antibodyAnti-C20orf42 antibodyAnti-KIND1 antibodyAnti-URP1 antibody |
Information sourced from Uniprot.org
