| Tissue Specificity | Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level). |
| Post Translational Modifications | Phosphorylated.highly phosphorylated in myoblasts and myotubes. Phosphorylation at Ser-108 promotes PGE2-EP4-mediated inhibition of inflammation. Dephosphorylated by protein phosphatase 2A (PP2A). |
| Function | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. Promotes ubiquitination and degradation of SLBP. Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling. |
| Protein Name | Protein Fem-1 Homolog AFem1aFem1-AlphaProstaglandin E Receptor 4-Associated Protein |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | MitochondrionCytoplasm |
| Alternative Antibody Names | Anti-Protein Fem-1 Homolog A antibodyAnti-Fem1a antibodyAnti-Fem1-Alpha antibodyAnti-Prostaglandin E Receptor 4-Associated Protein antibodyAnti-FEM1A antibodyAnti-EPRAP antibody |
Information sourced from Uniprot.org
