| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FANCE |
| Gene ID: | 2178 |
| Uniprot ID: | FANCE_HUMAN |
| Immunogen Region: | 1-255 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human FANCE (NP_068741.1). |
| Immunogen Sequence: | MATPDAGLPGAEGVEPAPWA QLEAPARLLLQALQAGPEGA RRGLGVLRALGSRGWEPFDW GRLLEALCREEPVVQGPDGR LELKPLLLRLPRICQRNLMS LLMAVRPSLPESGLLSVLQI AQQDLAPDPDAWLRALGELL RRDLGVGTSMEGASPLSERC QRQLQSLCRGLGLGGRRLKS PQAPDPEEEENRDSQQPGKR RKDSEEEAASPEGKRVPKRL RCWEEEEDHEKERPEHKSL |
| Post Translational Modifications | Phosphorylated. Phosphorylation by CHEK1 at Thr-346 and Ser-374 regulates its function in DNA cross-links repair. Ubiquitinated. Phosphorylation by CHEK1 induces polyubiquitination and degradation. |
| Function | As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. |
| Protein Name | Fanconi Anemia Group E ProteinProtein Face |
| Database Links | Reactome: R-HSA-6783310Reactome: R-HSA-9833482 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Fanconi Anemia Group E Protein antibodyAnti-Protein Face antibodyAnti-FANCE antibodyAnti-FACE antibody |
Information sourced from Uniprot.org