| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | EYA4 |
| Gene ID: | 2070 |
| Uniprot ID: | EYA4_HUMAN |
| Immunogen Region: | 1-300 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human EYA4 (NP_742101.2). |
| Immunogen Sequence: | MEDSQDLNEQSVKKTCTESD VSQSQNSRSMEMQDLASPHT LVGGGDTPGSSKLEKSNLSS TSVTTNGTGVSLLAVKTEPL NSSETTATTGDGALDTFTGS VITSSGYSPRSAHQYSPQLY PSKPYPHILSTPAAQTMSAY AGQTQYSGMQQPAVYTAYSQ TGQPYSLPTYDLGVMLPAIK TESGLSQTQSPLQSGCLSYS PGFSTPQPGQTPYSYQMPGS SFAPSSTIYANNSVSNSTN |
| Tissue Specificity | Highly expressed in heart and skeletal muscle. |
| Function | Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye. |
| Protein Name | Eyes Absent Homolog 4 |
| Database Links | Reactome: R-HSA-5693565 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Eyes Absent Homolog 4 antibodyAnti-EYA4 antibody |
Information sourced from Uniprot.org