| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ERRFI1 |
| Gene ID: | 54206 |
| Uniprot ID: | ERRFI_HUMAN |
| Immunogen Region: | 223-462 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 223-462 of human ERRFI1 (NP_061821.1). |
| Immunogen Sequence: | SYVSDQNGGVPDPNPPPPQT HRRLRRSHSGPAGSFNKPAI RISNCCIHRASPNSDEDKPE VPPRVPIPPRPVKPDYRRWS AEVTSSTYSDEDRPPKVPPR EPLSPSNSRTPSPKSLPSYL NGVMPPTQSFAPDPKYVSSK ALQRQNSEGSASKVPCILPI IENGKKVSSTHYYLLPERPP YLDKYEKFFREAEETNGGAQ IQPLPADCGISSATEKPDSK TKMDLGGHVKRKHLSYVVS |
| Function | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development. |
| Protein Name | Erbb Receptor Feedback Inhibitor 1 Mitogen-Inducible Gene 6 Protein Mig-6 |
| Cellular Localisation | Cytoplasm Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Nucleus Associated With The Plasma Membrane Of Basal Skin Keratinocytes Translocates Into The Nucleus Of Differentiating Suprabasal Keratinocytes |
| Alternative Antibody Names | Anti-Erbb Receptor Feedback Inhibitor 1 antibody Anti-Mitogen-Inducible Gene 6 Protein antibody Anti-Mig-6 antibody Anti-ERRFI1 antibody Anti-MIG6 antibody |
Information sourced from Uniprot.org