| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ERRFI1 (223-462) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ERRFI1 |
| Gene ID: |
54206 |
| Uniprot ID: |
ERRFI_HUMAN |
| Immunogen Region: |
223-462 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 223-462 of human ERRFI1 (NP_061821.1). |
| Immunogen Sequence: |
SYVSDQNGGVPDPNPPPPQT HRRLRRSHSGPAGSFNKPAI RISNCCIHRASPNSDEDKPE VPPRVPIPPRPVKPDYRRWS AEVTSSTYSDEDRPPKVPPR EPLSPSNSRTPSPKSLPSYL NGVMPPTQSFAPDPKYVSSK ALQRQNSEGSASKVPCILPI IENGKKVSSTHYYLLPERPP YLDKYEKFFREAEETNGGAQ IQPLPADCGISSATEKPDSK TKMDLGGHVKRKHLSYVVS |
| Function | Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development. |
| Protein Name | Erbb Receptor Feedback Inhibitor 1Mitogen-Inducible Gene 6 ProteinMig-6 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideNucleusAssociated With The Plasma Membrane Of Basal Skin KeratinocytesTranslocates Into The Nucleus Of Differentiating Suprabasal Keratinocytes |
| Alternative Antibody Names | Anti-Erbb Receptor Feedback Inhibitor 1 antibodyAnti-Mitogen-Inducible Gene 6 Protein antibodyAnti-Mig-6 antibodyAnti-ERRFI1 antibodyAnti-MIG6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
