| Post Translational Modifications | Phosphorylation by PLK1 prevents the association with chromosome arms and restricts its localization to the kinetochore-centromere region. |
| Function | DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro). |
| Protein Name | Dna Excision Repair Protein Ercc-6-LikeAtp-Dependent Helicase Ercc6-LikePlk1-Interacting Checkpoint HelicaseTumor Antigen Bj-Hcc-15 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | ChromosomeCentromereKinetochoreLocalizes To KinetochoresInner Centromeres And Thin Threads Connecting Separating Chromosomes Even During AnaphaseIn Prometaphase CellsIt Mostly Concentrates In Between KinetochoresIn MetaphaseIt Localizes To Numerous Thin Threads That Stretch Between Sister Kinetochores Of The Aligned Chromosomes And Are Composed Of Catenated Centromeric DnaEvolution From Inner Centromeres To Thin Threads Takes Place In Response To TensionResolution Of Thin Threads Requires Topoisomerase 2-Alpha (Top2a) After Anaphase Onset |
| Alternative Antibody Names | Anti-Dna Excision Repair Protein Ercc-6-Like antibodyAnti-Atp-Dependent Helicase Ercc6-Like antibodyAnti-Plk1-Interacting Checkpoint Helicase antibodyAnti-Tumor Antigen Bj-Hcc-15 antibodyAnti-ERCC6L antibodyAnti-PICH antibody |
Information sourced from Uniprot.org
