| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EPC1 |
| Gene ID: | 80314 |
| Uniprot ID: | EPC1_HUMAN |
| Immunogen Region: | 1-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human EPC1 (NP_079485.1). |
| Immunogen Sequence: | MSKLSFRARALDASKPLPVF RCEDLPDLHEYASINRAVPQ MPTGMEKEEESEHHLQRAIS AQQVYGEKRDNMVIPVPEAE SNIAYYESIYPGEFKMPKQL IHIQPFSLDAEQPDYDLDSE DEVFVNKLKKKMDICPLQFE EMIDRLEKGSGQQPVSLQEA KLLLKEDDELIREVYEYWIK KRKNCRGPSLIPSVKQEKRD GSSTNDPYVAFRRRTEKMQT RKNRKNDEASYEKMLKLRR |
| Function | Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids. In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex. |
| Protein Name | Enhancer Of Polycomb Homolog 1 |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-8953750 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Enhancer Of Polycomb Homolog 1 antibodyAnti-EPC1 antibody |
Information sourced from Uniprot.org