| Tissue Specificity | Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus, stomach and colon. |
| Post Translational Modifications | N-glycosylated.required for activity and transport to the plasma membrane. |
| Function | Choline-specific phosphodiesterase that hydrolyzes sphingomyelin releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract. Has also phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation. Does not have nucleotide pyrophosphatase activity. May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen. |
| Protein Name | Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 7E-Npp 7Npp-7Alkaline Sphingomyelin PhosphodiesteraseIntestinal Alkaline SphingomyelinaseAlk-Smase |
| Database Links | Reactome: R-HSA-9840310 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinThe Catalytic Domain Is Released Into The Extracellular Medium When Cells Are Treated With TrypsinLocalized At The Surface Of The Microvillar Membrane In Small Intestine EnterocytesAnd In Endosome-Like Structures Situated Beneath The Microvillar MembraneAnd In Golgi Complex |
| Alternative Antibody Names | Anti-Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 7 antibodyAnti-E-Npp 7 antibodyAnti-Npp-7 antibodyAnti-Alkaline Sphingomyelin Phosphodiesterase antibodyAnti-Intestinal Alkaline Sphingomyelinase antibodyAnti-Alk-Smase antibodyAnti-ENPP7 antibodyAnti-UNQ3077 antibodyAnti-PRO9912 antibody |
Information sourced from Uniprot.org
