| Tissue Specificity | Not abundant.expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord. |
| Post Translational Modifications | N-glycosylated. Processing by furin produces a secreted form. |
| Function | Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. May also play a role in cell adhesion. Isoform 1: Binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor EDA2R. Isoform 3: Binds only to the receptor EDA2R. |
| Protein Name | Ectodysplasin-AEctodermal Dysplasia ProteinEda Protein Cleaved Into - Ectodysplasin-A - Membrane Form - Ectodysplasin-A - Secreted Form |
| Database Links | Reactome: R-HSA-5669034 Q92838-3 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinEctodysplasin-ASecreted Form: Secreted |
| Alternative Antibody Names | Anti-Ectodysplasin-A antibodyAnti-Ectodermal Dysplasia Protein antibodyAnti-Eda Protein Cleaved Into - Ectodysplasin-A - Membrane Form - Ectodysplasin-A - Secreted Form antibodyAnti-EDA antibodyAnti-ED1 antibodyAnti-EDA2 antibody |
Information sourced from Uniprot.org
