| Tissue Specificity | Expressed in colon, small intestine, duodenum and tracheal surface epithelial cells (at protein level). Expressed in thyrocytes. Also detected in kidney, liver, lung, pancreas, prostate, salivary glands, rectum and testis. |
| Post Translational Modifications | N-glycosylated. |
| Function | Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. |
| Protein Name | Dual Oxidase 2Large Nox 2Long Nox 2Nadh/Nadph Thyroid Oxidase P138-ToxNadph Oxidase/Peroxidase Duox2Nadph Thyroid Oxidase 2Thyroid Oxidase 2P138 Thyroid Oxidase |
| Database Links | Reactome: R-HSA-209968 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell JunctionLocalizes To The Apical Membrane Of Epithelial CellsLocalizes On Internal Membrane Structures Under Resting ConditionsTranslocates To The Plasma Membrane And Cell-Cell Junctions Upon Challenge With Enteric PathogensSuch As Escherichia Coli |
| Alternative Antibody Names | Anti-Dual Oxidase 2 antibodyAnti-Large Nox 2 antibodyAnti-Long Nox 2 antibodyAnti-Nadh/Nadph Thyroid Oxidase P138-Tox antibodyAnti-Nadph Oxidase/Peroxidase Duox2 antibodyAnti-Nadph Thyroid Oxidase 2 antibodyAnti-Thyroid Oxidase 2 antibodyAnti-P138 Thyroid Oxidase antibodyAnti-DUOX2 antibodyAnti-LNOX2 antibodyAnti-THOX2 antibody |
Information sourced from Uniprot.org
