| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DPT (19-201) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DPT |
| Gene ID: |
1805 |
| Uniprot ID: |
DERM_HUMAN |
| Immunogen Region: |
19-201 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 19-201 of human DPT (NP_001928.2). |
| Immunogen Sequence: |
QYGDYGYPYQQYHDYSDDGW VNLNRQGFSYQCPQGQVIVA VRSIFSKKEGSDRQWNYACM PTPQSLGEPTECWWEEINRA GMEWYQTCSNNGLVAGFQSR YFESVLDREWQFYCCRYSKR CPYSCWLTTEYPGHYGEEMD MISYNYDYYIRGATTTFSAV ERDRQWKFIMCRMTEYDCEF ANV |
| Tissue Specificity | Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts. |
| Post Translational Modifications | Sulfated on tyrosine residue(s). |
| Function | Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation. |
| Protein Name | DermatopontinTyrosine-Rich Acidic Matrix ProteinTramp |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Dermatopontin antibodyAnti-Tyrosine-Rich Acidic Matrix Protein antibodyAnti-Tramp antibodyAnti-DPT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
