| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DOK4 |
| Gene ID: | 55715 |
| Uniprot ID: | DOK4_HUMAN |
| Immunogen Region: | 1-326 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-326 of human DOK4 (NP_060580.2). |
| Immunogen Sequence: | MATNFSDIVKQGYVKMKSRK LGIYRRCWLVFRKSSSKGPQ RLEKYPDEKSVCLRGCPKVT EISNVKCVTRLPKETKRQAV AIIFTDDSARTFTCDSELEA EEWYKTLSVECLGSRLNDIS LGEPDLLAPGVQCEQTDRFN VFLLPCPNLDVYGECKLQIT HENIYLWDIHNPRVKLVSWP LCSLRRYGRDATRFTFEAGR MCDAGEGLYTFQTQEGEQIY QRVHSATLAIAEQHKRVLL |
| Tissue Specificity | Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells. |
| Post Translational Modifications | Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation. |
| Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. |
| Protein Name | Docking Protein 4Downstream Of Tyrosine Kinase 4Insulin Receptor Substrate 5Irs-5Irs5 |
| Database Links | Reactome: R-HSA-8853659 |
| Alternative Antibody Names | Anti-Docking Protein 4 antibodyAnti-Downstream Of Tyrosine Kinase 4 antibodyAnti-Insulin Receptor Substrate 5 antibodyAnti-Irs-5 antibodyAnti-Irs5 antibodyAnti-DOK4 antibody |
Information sourced from Uniprot.org