| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DIS3L |
| Gene ID: | 115752 |
| Uniprot ID: | DI3L1_HUMAN |
| Immunogen Region: | 1-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human DIS3L (NP_588616.1). |
| Immunogen Sequence: | MQTACQAVQHQRGRRQYNKL RNLLKDARHDCILFANEFQQ CCYLPRERGESMEKWQTRSI YNAAVWYYHHCQDRMPIVMV TEDEEAIQQYGSETEGVFVI TFKNYLDNFWPDLKAAHELC DSILQSRRERENESQESHGK EYPEHLPLEVLEAGIKSGRY IQGILNVNKHRAQIEAFVRL QGASSKDSDLVSDILIHGMK ARNRSIHGDVVVVELLPKNE WKGRTVALCENDCDDKASG |
| Function | Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. |
| Protein Name | Dis3-Like Exonuclease 1 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dis3-Like Exonuclease 1 antibodyAnti-DIS3L antibodyAnti-DIS3L1 antibodyAnti-KIAA1955 antibody |
Information sourced from Uniprot.org