| Post Translational Modifications | Ubiquitinated, leading to its degradation by the proteasome. Deubiquitinated by USP36. |
| Function | Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing. Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation. Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells. Required for NLRP3 activation induced by viral dsRNA and bacterial RNA. In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways. |
| Protein Name | Atp-Dependent Rna Helicase Dhx33Deah Box Protein 33 |
| Cellular Localisation | NucleusNucleolusNucleoplasmCytoplasmInflammasomePredominantly In The NucleolusDuring MitosisLocalizes With The Nucleolar Organizing RegionsUpon Dsrna-BindingLocalizes In The Inflammasome |
| Alternative Antibody Names | Anti-Atp-Dependent Rna Helicase Dhx33 antibodyAnti-Deah Box Protein 33 antibodyAnti-DHX33 antibodyAnti-DDX33 antibody |
Information sourced from Uniprot.org
