| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DHODH |
| Gene ID: | 1723 |
| Uniprot ID: | PYRD_HUMAN |
| Immunogen Region: | 116-395 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 116-395 of human DHODH (NP_001352.2). |
| Immunogen Sequence: | EIGSVTPKPQEGNPRPRVFR LPEDQAVINRYGFNSHGLSV VEHRLRARQQKQAKLTEDGL PLGVNLGKNKTSVDAAEDYA EGVRVLGPLADYLVVNVSSP NTAGLRSLQGKAELRRLLTK VLQERDGLRRVHRPAVLVKI APDLTSQDKEDIASVVKELG IDGLIVTNTTVSRPAGLQGA LRSETGGLSGKPLRDLSTQT IREMYALTQGRVPIIGVGGV SSGQDALEKIRAGASLVQL |
| Post Translational Modifications | The uncleaved transit peptide is required for mitochondrial targeting and proper membrane integration. |
| Function | Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway. |
| Protein Name | Dihydroorotate DehydrogenaseQuinone - MitochondrialDhodehaseDihydroorotate Oxidase |
| Database Links | Reactome: R-HSA-500753 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Dihydroorotate Dehydrogenase antibodyAnti-Quinone - Mitochondrial antibodyAnti-Dhodehase antibodyAnti-Dihydroorotate Oxidase antibodyAnti-DHODH antibody |
Information sourced from Uniprot.org