| Function | ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm. |
| Protein Name | Atp-Dependent Rna Helicase Ddx42Dead Box Protein 42Rna Helicase-Like ProteinRhelpRna Helicase-Related ProteinRnahpSf3b Dead Box ProteinSplicing Factor 3b-Associated 125 Kda ProteinSf3b125 |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72165 |
| Cellular Localisation | CytoplasmNucleusIsoform 2: NucleusCajal BodyNucleus Speckle |
| Alternative Antibody Names | Anti-Atp-Dependent Rna Helicase Ddx42 antibodyAnti-Dead Box Protein 42 antibodyAnti-Rna Helicase-Like Protein antibodyAnti-Rhelp antibodyAnti-Rna Helicase-Related Protein antibodyAnti-Rnahp antibodyAnti-Sf3b Dead Box Protein antibodyAnti-Splicing Factor 3b-Associated 125 Kda Protein antibodyAnti-Sf3b125 antibodyAnti-DDX42 antibody |
Information sourced from Uniprot.org
