| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DCXR (1-244) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DCXR |
| Gene ID: |
51181 |
| Uniprot ID: |
DCXR_HUMAN |
| Immunogen Region: |
1-244 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-244 of human DCXR (NP_057370.1). |
| Immunogen Sequence: |
MELFLAGRRVLVTGAGKGIG RGTVQALHATGARVVAVSRT QADLDSLVRECPGIEPVCVD LGDWEATERALGSVGPVDLL VNNAAVALLQPFLEVTKEAF DRSFEVNLRAVIQVSQIVAR GLIARGVPGAIVNVSSQCSQ RAVTNHSVYCSTKGALDMLT KVMALELGPHKIRVNAVNPT VVMTSMGQATWSDPHKAKTM LNRIPLGKFAEVEHVVNAIL FLLSDRSGMTTGSTLPVEG |
| Tissue Specificity | Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis. |
| Function | Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. |
| Protein Name | L-Xylulose ReductaseXrCarbonyl Reductase IiDicarbonyl/L-Xylulose ReductaseKidney Dicarbonyl ReductaseKidcrShort Chain Dehydrogenase/Reductase Family 20c Member 1Sperm Surface Protein P34h |
| Database Links | Reactome: R-HSA-5661270Reactome: R-HSA-5662853 |
| Cellular Localisation | MembranePeripheral Membrane ProteinProbably Recruited To Membranes Via An Interaction With Phosphatidylinositol |
| Alternative Antibody Names | Anti-L-Xylulose Reductase antibodyAnti-Xr antibodyAnti-Carbonyl Reductase Ii antibodyAnti-Dicarbonyl/L-Xylulose Reductase antibodyAnti-Kidney Dicarbonyl Reductase antibodyAnti-Kidcr antibodyAnti-Short Chain Dehydrogenase/Reductase Family 20c Member 1 antibodyAnti-Sperm Surface Protein P34h antibodyAnti-DCXR antibodyAnti-SDR20C1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
