| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CYP26B1 (213-512) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP26B1 |
| Gene ID: |
56603 |
| Uniprot ID: |
CP26B_HUMAN |
| Immunogen Region: |
213-512 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 213-512 of human CYP26B1 (NP_063938.1). |
| Immunogen Sequence: |
VYQQFVDNVFSLPVDLPFSG YRRGIQARQILQKGLEKAIR EKLQCTQGKDYLDALDLLIE SSKEHGKEMTMQELKDGTLE LIFAAYATTASASTSLIMQL LKHPTVLEKLRDELRAHGIL HSGGCPCEGTLRLDTLSGLR YLDCVIKEVMRLFTPISGGY RTVLQTFELDGFQIPKGWSV MYSIRDTHDTAPVFKDVNVF DPDRFSQARSEDKDGRFHYL PFGGGVRTCLGKHLAKLFL |
| Tissue Specificity | Highly expressed in brain, particularly in the cerebellum and pons. |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals. RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling. Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination. Involved in the convertion of atRA to all-trans-4-oxo-RA. Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA. Shows preference for the following substrates: atRA > 9-cis-RA > 13-cis-RA. Plays a central role in germ cell development: acts by degrading RAs in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. Essential for postnatal survival. Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo. |
| Protein Name | Cytochrome P450 26b1Cytochrome P450 26a2Cytochrome P450 Retinoic Acid-Inactivating 2Cytochrome P450rai-2Retinoic Acid-Metabolizing Cytochrome |
| Database Links | Reactome: R-HSA-211916Reactome: R-HSA-5365859Reactome: R-HSA-5579015 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 26b1 antibodyAnti-Cytochrome P450 26a2 antibodyAnti-Cytochrome P450 Retinoic Acid-Inactivating 2 antibodyAnti-Cytochrome P450rai-2 antibodyAnti-Retinoic Acid-Metabolizing Cytochrome antibodyAnti-CYP26B1 antibodyAnti-CYP26A2 antibodyAnti-P450RAI2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
