| Tissue Specificity | Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues. |
| Post Translational Modifications | Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). N- and O-glycosylated. N-glycosylation is required for optimal proteolytic activation. O-glycosylated with core 1 or possibly core 8 glycans. Ubiquitinated at Lys-294 by SYNV1/HRD1 via 'Lys-27'-linked ubiquitin. |
| Function | Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE. May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription. Plays a crucial role in the regulation of triglyceride metabolism and is required for the maintenance of normal plasma triglyceride concentrations. |
| Protein Name | Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 3Camp-Responsive Element-Binding Protein 3-Like Protein 3Transcription Factor Creb-H Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 3 |
| Database Links | Reactome: R-HSA-8874211Reactome: R-HSA-8963889 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinProcessed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 3: NucleusUnder Er Stress The Cleaved N-Terminal Cytoplasmic Domain Translocates Into The Nucleus |
| Alternative Antibody Names | Anti-Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 3 antibodyAnti-Camp-Responsive Element-Binding Protein 3-Like Protein 3 antibodyAnti-Transcription Factor Creb-H Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 3 antibodyAnti-CREB3L3 antibodyAnti-CREBH antibodyAnti-HYST1481 antibody |
Information sourced from Uniprot.org
