Western blot analysis of various lysates using CPLX3 Rabbit pAb (STJ115649) at 1:3000 dilution. <br/>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br/>Lysates/proteins: 25 Mu g per lane. <br/>Blocking buffer: 3% nonfat dry milk in TBST. <br/>Detection: ECL Enhanced Kit <br/>Exposure time: 90s.

Anti-CPLX3 antibody (59-158) (STJ115649)

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STJ115649
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CPLX3
Gene ID: 594855
Uniprot ID: CPLX3_HUMAN
Immunogen Region: 59-158
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 59-158 of human CPLX3 (NP_001025176.1).
Immunogen Sequence: DAQFTQRKAERATLRSHFRD KYRLPKNETDESQIQMAGGD VELPRELAKMIEEDTEEEEE KASVLGQLASLPGLNLGSLK DKAQATLGDLKQSAEKCHVM
Post Translational Modifications Farnesylation mediates presynaptic targeting.
Function Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion. Required for the maintenance of synaptic ultrastructure in the adult retina. Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina. Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release.
Protein Name Complexin-3
Complexin Iii
Cpx Iii
Cellular Localisation Synapse
Cell Membrane
Lipid-Anchor
Enriched At The Synaptic Terminal
Localized At Glycinergic Synaptic Contacts Of Aii Amacrine Cells With Off Cone Bipolar Cells In The Off Sublamina Of The Retina Inner Nuclear Layer
Alternative Antibody Names Anti-Complexin-3 antibody
Anti-Complexin Iii antibody
Anti-Cpx Iii antibody
Anti-CPLX3 antibody
Anti-Nbla11589 antibody

Information sourced from Uniprot.org

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