| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CPE |
| Gene ID: | 1363 |
| Uniprot ID: | CBPE_HUMAN |
| Immunogen Region: | 257-476 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 257-476 of human CPE (NP_001864.1). |
| Immunogen Sequence: | PYDETRSGSAHEYSSSPDDA IFQSLARAYSSFNPAMSDPN RPPCRKNDDDSSFVDGTTNG GAWYSVPGGMQDFNYLSSNC FEITVELSCEKFPPEETLKT YWEDNKNSLISYLEQIHRGV KGFVRDLQGNPIANATISVE GIDHDVTSAKDGDYWRLLIP GNYKLTASAPGYLAITKKVA VPYSPAAGVDFELESFSERK EEEKEELMEWWKMMSETLNF |
| Function | Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. |
| Protein Name | Carboxypeptidase ECpeCarboxypeptidase HCphEnkephalin ConvertaseProhormone-Processing Carboxypeptidase |
| Database Links | Reactome: R-HSA-264876 |
| Cellular Localisation | Isoform 1: Cytoplasmic VesicleSecretory VesicleCytoplasmic VesicleSecretory Vesicle MembranePeripheral Membrane ProteinSecretedAssociated With The Secretory Granule Membrane Through Direct Binding To Lipid Rafts In Intragranular Conditions |
| Alternative Antibody Names | Anti-Carboxypeptidase E antibodyAnti-Cpe antibodyAnti-Carboxypeptidase H antibodyAnti-Cph antibodyAnti-Enkephalin Convertase antibodyAnti-Prohormone-Processing Carboxypeptidase antibodyAnti-CPE antibody |
Information sourced from Uniprot.org