| Function | Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 7Btg1-Binding Factor 1Ccr4-Associated Factor 1Caf-1Caf1a |
| Database Links | Reactome: R-HSA-429947Reactome: R-HSA-6804115Reactome: R-HSA-9820841 |
| Cellular Localisation | NucleusCytoplasmP-BodyCytoplasmic Ribonucleoprotein GranuleNanos2 Promotes Its Localization To P-BodyRecruited To Cytoplasmic Ribonucleoprotein Membraneless Compartments By Caprin1Promoting Deadenylation Of Mrnas |
| Alternative Antibody Names | Anti-Ccr4-Not Transcription Complex Subunit 7 antibodyAnti-Btg1-Binding Factor 1 antibodyAnti-Ccr4-Associated Factor 1 antibodyAnti-Caf-1 antibodyAnti-Caf1a antibodyAnti-CNOT7 antibodyAnti-CAF1 antibody |
Information sourced from Uniprot.org
