| Tissue Specificity | Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level). |
| Post Translational Modifications | Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by presenilin gamma-secretase within the transmembrane domain releases the beta-Alc-alpha chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1. |
| Function | Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation. Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane. Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. Soluble Alc-alpha: As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. CTF1-alpha: In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. |
| Protein Name | Calsyntenin-1Alcadein-AlphaAlc-AlphaAlzheimer-Related Cadherin-Like ProteinNon-Classical Cadherin Xb31alpha Cleaved Into - Soluble Alc-AlphaSalc-Alpha - Ctf1-AlphaC-Terminal Fragment 1-Alpha |
| Cellular Localisation | Postsynaptic Cell MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum MembraneGolgi Apparatus MembraneCell ProjectionNeuron ProjectionLocalized In The Postsynaptic Membrane Of Both Excitatory And Inhibitory SynapsesSoluble Alc-Alpha: NucleusThe Alcicd Fragment Is Translocated To The Nucleus Upon Interaction With Apbb1 |
| Alternative Antibody Names | Anti-Calsyntenin-1 antibodyAnti-Alcadein-Alpha antibodyAnti-Alc-Alpha antibodyAnti-Alzheimer-Related Cadherin-Like Protein antibodyAnti-Non-Classical Cadherin Xb31alpha Cleaved Into - Soluble Alc-Alpha antibodyAnti-Salc-Alpha - Ctf1-Alpha antibodyAnti-C-Terminal Fragment 1-Alpha antibodyAnti-CLSTN1 antibodyAnti-CS1 antibodyAnti-KIAA0911 antibody |
Information sourced from Uniprot.org
