| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLPX (500-600) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLPX |
| Gene ID: |
10845 |
| Uniprot ID: |
CLPX_HUMAN |
| Immunogen Region: |
500-600 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human CLPX (NP_006651.2). |
| Immunogen Sequence: |
LPVVVPLHSLDEKTLVQILT EPRNAVIPQYQALFSMDKCE LNVTEDALKAIARLALERKT GARGLRSIMEKLLLEPMFEV PNSDIVCVEVDKEVVEGKKE P |
| Tissue Specificity | Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas. |
| Function | ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex. Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure. ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. Important for efficient erythropoiesis through up-regulation of heme biosynthesis. |
| Protein Name | Atp-Dependent Clp Protease Atp-Binding Subunit Clpx-Like - Mitochondrial |
| Cellular Localisation | MitochondrionMitochondrion MatrixMitochondrion Nucleoid |
| Alternative Antibody Names | Anti-Atp-Dependent Clp Protease Atp-Binding Subunit Clpx-Like - Mitochondrial antibodyAnti-CLPX antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
