• Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200
  • Western blot analysis of HEPG2 cells using CLECSF6 Polyclonal Antibody diluted at 1:500. Secondary antibody was diluted at 1:20000

Anti-CLEC4A antibody (161-210 aa) (STJ98638)

SKU:
STJ98638

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-C-type lectin domain family 4 member A (161-210 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:10000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CLEC4A
Gene ID: 50856
Uniprot ID: CLC4A_HUMAN
Immunogen Region: 161-210 aa
Specificity: CLECSF6 Polyclonal Antibody detects endogenous levels of CLECSF6
Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human CLEC4A at the amino acid range 161-210
Function C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. (Microbial infection) Involved in the interaction between HIV-1 virus and dendritic cells. Enhances HIV-1 binding/entry and virus infection. Requires ITIM motif-associated signal transduction pathway involving phosphatases PTPN6 and PTPN11, SYK, Src kinases and MAP kinases.
Protein Name C-Type Lectin Domain Family 4 Member A
C-Type Lectin Ddb27
C-Type Lectin Superfamily Member 6
Dendritic Cell Immunoreceptor
Lectin-Like Immunoreceptor
Cd Antigen Cd367
Database Links Reactome: R-HSA-5621480
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Extracellular Side
Alternative Antibody Names Anti-C-Type Lectin Domain Family 4 Member A antibody
Anti-C-Type Lectin Ddb27 antibody
Anti-C-Type Lectin Superfamily Member 6 antibody
Anti-Dendritic Cell Immunoreceptor antibody
Anti-Lectin-Like Immunoreceptor antibody
Anti-Cd Antigen Cd367 antibody
Anti-CLEC4A antibody
Anti-CLECSF6 antibody
Anti-DCIR antibody
Anti-LLIR antibody
Anti-HDCGC13P antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance