| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CLEC16A |
| Gene ID: | 23274 |
| Uniprot ID: | CL16A_HUMAN |
| Immunogen Region: | 330-550 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 330-550 of human CLEC16A (NP_001230332.1). |
| Immunogen Sequence: | SLAEVILNGDLSEMYAKTEQ DIQRSSAKPSIRCFIKPTET LERSLEMNKHKGKRRVQKRP NYKNVGEEEDEEKGPTEDAQ EDAEKAKEIEMVIMERSKLS ELAASTSVQEQNTTDEEKSA AATCSESTQWSRPFLDMVYH ALDSPDDDYHALFVLCLLYA MSHNKGMDPEKLERIQLPVP NAAEKTTYNHPLAERLIRIM NNAAQPDGKIRLATLELSCL L |
| Tissue Specificity | Almost exclusively expressed in immune cells, including dendritic cells, B-lymphocytes and natural killer cells. |
| Function | Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteasomal degradation, RNF41/NRDP1 which regulates proteasomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. |
| Protein Name | Protein Clec16aC-Type Lectin Domain Family 16 Member A |
| Cellular Localisation | Endosome MembranePeripheral Membrane ProteinLysosome MembraneAssociates With The Endolysosome Membrane |
| Alternative Antibody Names | Anti-Protein Clec16a antibodyAnti-C-Type Lectin Domain Family 16 Member A antibodyAnti-CLEC16A antibodyAnti-KIAA0350 antibody |
Information sourced from Uniprot.org