| Post Translational Modifications | Phosphorylated at Tyr-7 by SRC in the ITIM motif following ligand-binding, promoting recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11. Highly N-glycosylated.glycosylation varies between cell types. |
| Function | Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation. Myeloid cell inhibition is required to limit proinflammatory pathways and protect against excessive inflammation. Specifically recognizes and binds various structures, such as neutrophil extracellular traps (NETs) or monosodium urate crystals. Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid. Ligand-binding induces phosphorylation of its ITIM motif, followed by recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11, which counteract tyrosine-protein kinase SYK, thereby preventing myeloid cell activation. Acts as a pattern-recognition receptor for NETs in neutrophils: specifically recognizes DNA in NETs, leading to inhibit neutrophil activation and limit further NET formation. This regulation is essential for controlling key neutrophil responses and limit NET-mediated inflammatory conditions. Also recognizes dead cells by acting as a receptor for monosodium urate crystals, leading to down-regulate neutrophil activation. Binding to monosodium urate crystals also promotes the type I interferon response. Acts as an inhibitor of natural killer (NK) cell cytotoxicity. Also acts as an ihibitor of dendritic cell maturation in an IL10-dependent manner. |
| Protein Name | C-Type Lectin Domain Family 12 Member AC-Type Lectin-Like Molecule 1Cll-1Dendritic Cell-Associated Lectin 2Dcal-2Killer Cell C-Type Lectin-Like Receptor L1Hklrl1Myeloid Inhibitory C-Type Lectin-Like ReceptorMiclCd Antigen Cd371 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinLigand Binding Leads To InternalizationClusters At Phagocytic Vesicles Upon Monosodium Urate Crystal-Binding |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 12 Member A antibodyAnti-C-Type Lectin-Like Molecule 1 antibodyAnti-Cll-1 antibodyAnti-Dendritic Cell-Associated Lectin 2 antibodyAnti-Dcal-2 antibodyAnti-Killer Cell C-Type Lectin-Like Receptor L1 antibodyAnti-Hklrl1 antibodyAnti-Myeloid Inhibitory C-Type Lectin-Like Receptor antibodyAnti-Micl antibodyAnti-Cd Antigen Cd371 antibodyAnti-CLEC12A antibodyAnti-CLL1 antibodyAnti-DCAL2 antibodyAnti-KLRL1 antibodyAnti-MICL antibody |
Information sourced from Uniprot.org
