| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLDN8 |
| Gene ID: |
9073 |
| Uniprot ID: |
CLD8_HUMAN |
| Immunogen Region: |
29-81 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 29-81 of human CLDN8 (NP_955360.1). |
| Immunogen Sequence: |
QWRVSAFIENNIVVFENFWE GLWMNCVRQANIRMQCKIYD SLLALSPDLQAAR |
| Tissue Specificity | Expressed in the epididymis, mainly in the caput segment. |
| Post Translational Modifications | Ubiquitinated by the BCR(KLHL3) E3 ubiquitin ligase complex in the kidney, leading to its degradation. |
| Function | Can associate with other claudins to regulate tight junction structural and functional strand dynamics. May coassemble with CLDN4 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts. Cannot form tight junction strands on its own. |
| Protein Name | Claudin-8 |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane ProteinLocalizes To Tight Junctions In All 3 Segments Of The EpididymisIn The Caput Found In The Lateral Margins Of Principal CellsAnd In The Corpus At The Interface Between Basal And Principal Cells |
| Alternative Antibody Names | Anti-Claudin-8 antibodyAnti-CLDN8 antibodyAnti-UNQ779 antibodyAnti-PRO1573 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
