Tissue Specificity | Expressed in the epididymis, mainly in the caput segment. |
Post Translational Modifications | Ubiquitinated by the BCR(KLHL3) E3 ubiquitin ligase complex in the kidney, leading to its degradation. |
Function | Can associate with other claudins to regulate tight junction structural and functional strand dynamics. May coassemble with CLDN4 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts. Cannot form tight junction strands on its own. |
Protein Name | Claudin-8 |
Database Links | Reactome: R-HSA-420029 |
Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane ProteinLocalizes To Tight Junctions In All 3 Segments Of The EpididymisIn The Caput Found In The Lateral Margins Of Principal CellsAnd In The Corpus At The Interface Between Basal And Principal Cells |
Alternative Antibody Names | Anti-Claudin-8 antibodyAnti-CLDN8 antibodyAnti-UNQ779 antibodyAnti-PRO1573 antibody |
Information sourced from Uniprot.org