| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLCN4 (600-700) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLCN4 |
| Gene ID: |
1183 |
| Uniprot ID: |
CLCN4_HUMAN |
| Immunogen Region: |
600-700 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 600-700 of human CLCN4 (NP_001821.2). |
| Immunogen Sequence: |
MRPRRGEPPLSVLTQDSMTV EDVETLIKETDYNGFPVVVS RDSERLIGFAQRRELILAIK NARQRQEGIVSNSIMYFTEE PPELPANSPHPLKLRRILNL S |
| Tissue Specificity | Abundant in skeletal muscle and also detectable in brain and heart. |
| Function | Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. |
| Protein Name | H(+/Cl(- Exchange Transporter 4Chloride Channel Protein 4Clc-4Chloride Transporter Clc-4 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Early Endosome MembraneMulti-Pass Membrane ProteinLate Endosome MembraneEndoplasmic Reticulum MembraneLysosome MembraneRecycling Endosome MembraneLocalizes To Late Endosome MembraneLysosome Membrane And Recycling Endosome Membrane In The Presence Of Clcn3 |
| Alternative Antibody Names | Anti-H(+/Cl(- Exchange Transporter 4 antibodyAnti-Chloride Channel Protein 4 antibodyAnti-Clc-4 antibodyAnti-Chloride Transporter Clc-4 antibodyAnti-CLCN4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
