| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLASP2 (220-400) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLASP2 |
| Gene ID: |
23122 |
| Uniprot ID: |
CLAP2_HUMAN |
| Immunogen Region: |
220-400 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 220-400 of human CLASP2 (NP_001193973.1). |
| Immunogen Sequence: |
NCTSKSVPVRRRSFEFLDLL LQEWQTHSLERHAAVLVETI KKGIHDADAEARVEARKTYM GLRNHFPGEAETLYNSLEPS YQKSLQTYLKSSGSVASLPQ SDRSSSSSQESLNRPFSSKW STANPSTVAGRVSAGSSKAS SLPGSLQRSRSDIDVNAAAG AKAHHAAGQSVRSGRLGAGA L |
| Tissue Specificity | Brain-specific. |
| Post Translational Modifications | Phosphorylated by GSK3B. Phosphorylation reduces MAPRE1 binding. Phosphorylation by GSK3B may negatively regulate binding to microtubule lattices in lamella. |
| Function | Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. |
| Protein Name | Clip-Associating Protein 2Cytoplasmic Linker-Associated Protein 2Protein Orbit Homolog 2Horbit2 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-428890Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeChromosomeCentromereKinetochoreSpindleGolgi ApparatusTrans-Golgi NetworkCell MembraneCell ProjectionRuffle MembraneLocalizes To Microtubule Plus EndsLocalizes To CentrosomesKinetochores And The Mitotic Spindle From PrometaphaseSubsequently Localizes To The Spindle Midzone From Anaphase And To The Midbody From TelophaseIn Migrating Cells Localizes To The Plus Ends Of Microtubules Within The Cell Body And To The Entire Microtubule Lattice Within The LamellaLocalizes To The Cell Cortex And This Requires Erc1 And Phldb2The Memo1-Rhoa-Diaph1 Signaling Pathway Controls Localization Of The Phosphorylated Form To The Cell Membrane |
| Alternative Antibody Names | Anti-Clip-Associating Protein 2 antibodyAnti-Cytoplasmic Linker-Associated Protein 2 antibodyAnti-Protein Orbit Homolog 2 antibodyAnti-Horbit2 antibodyAnti-CLASP2 antibodyAnti-KIAA0627 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
