| Post Translational Modifications | Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional coactivator activity. |
| Function | Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling.stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. |
| Protein Name | Cbp/P300-Interacting Transactivator 1Melanocyte-Specific Protein 1 |
| Database Links | Reactome: R-HSA-8866907Reactome: R-HSA-9018519 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Nucleus And The Cytoplasm By A Nuclear Export Signal And (Nes) In A Crm1-Dependent Manner |
| Alternative Antibody Names | Anti-Cbp/P300-Interacting Transactivator 1 antibodyAnti-Melanocyte-Specific Protein 1 antibodyAnti-CITED1 antibodyAnti-MSG1 antibody |
Information sourced from Uniprot.org
