| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Calcium and integrin-binding family member 2 (21-70 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CIB2 |
| Gene ID: |
10518 |
| Uniprot ID: |
CIB2_HUMAN |
| Immunogen Region: |
21-70 aa |
| Specificity: |
CIB2 Polyclonal Antibody detects endogenous levels of CIB2 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human CIB2 at the amino acid range 21-70 |
| Function | Calcium- and integrin-binding protein that plays a role in intracellular calcium homeostasis. Acts as a auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells. Essential for mechanoelectrical transduction (MET) currents in auditory hair cells and thereby required for hearing. Regulates the function of hair cell mechanotransduction by controlling the distribution of transmembrane channel-like proteins TMC1 and TMC2, and by regulating the function of the MET channels in hair cells. Required for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea. Critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release. |
| Protein Name | Calcium And Integrin-Binding Family Member 2Kinase-Interacting Protein 2Kip 2 |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | CytoplasmCell ProjectionStereociliumPhotoreceptor Inner SegmentCiliumPhotoreceptor Outer SegmentCell MembraneSarcolemmaColocalizes With Itga7 At The Myotendinous Junctions (Mtj) And At The Neuromuscular Junctions (Nmj)Located Mainly In Stereocilia And At The Apical Surface Of Hair Cells Of The CochleaLocalizes In The Cuticular Plate Along And At The Tip Of The Stereocilia Of Vestibular Sensory Hair Cells |
| Alternative Antibody Names | Anti-Calcium And Integrin-Binding Family Member 2 antibodyAnti-Kinase-Interacting Protein 2 antibodyAnti-Kip 2 antibodyAnti-CIB2 antibodyAnti-KIP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
