| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CHRM3 (390-475) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CHRM3 |
| Gene ID: |
1131 |
| Uniprot ID: |
ACM3_HUMAN |
| Immunogen Region: |
390-475 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 390-475 of human CHRM3 (NP_000731.1). |
| Immunogen Sequence: |
QVPEEELGMVDLERKADKLQ AQKSVDDGGSFPKSFSKLPI QLESAVDTAKTSDVNSSVGK STATLPLSFKEATLAKRFAL KTRSQI |
| Function | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. |
| Protein Name | Muscarinic Acetylcholine Receptor M3 |
| Database Links | Reactome: R-HSA-390648Reactome: R-HSA-399997Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneBasolateral Cell MembraneEndoplasmic Reticulum MembraneColocalizes With Tmem147 In The Endoplasmic Reticulum (Er) MembraneTmem147 Impairs Its Trafficking To The Cell Membrane Leading To Its Retention In The Er Membrane |
| Alternative Antibody Names | Anti-Muscarinic Acetylcholine Receptor M3 antibodyAnti-CHRM3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
