| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CHL1 (690-950) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CHL1 |
| Gene ID: |
10752 |
| Uniprot ID: |
NCHL1_HUMAN |
| Immunogen Region: |
690-950 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 690-950 of human CHL1 (NP_001240316.1). |
| Immunogen Sequence: |
NEVGRSQPSQPSDHHETPPA APDRNPQNIRVQASQPKEMI IKWEPLKSMEQNGPGLEYRV TWKPQGAPVEWEEETVTNHT LRVMTPAVYAPYDVKVQAIN QLGSGPDPQSVTLYSGEDYP DTAPVIHGVDVINSTLVKVT WSTVPKDRVHGRLKGYQINW WKTKSLLDGRTHPKEVNILR FSGQRNSGMVPSLDAFSEFH LTVLAYNSKGAGPESEPYIF QTPEGVPEQPTFLKVIKVD |
| Tissue Specificity | Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues. |
| Post Translational Modifications | Cleavage by metalloprotease ADAM8 in the extracellular part generates 2 soluble forms (125 kDa and 165 kDa) in vitro and is inhibited by metalloprotease inhibitors. Cleaved by BACE1. N-glycosylated. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type HNK-1 (SO4-3-GlcUABeta1,3GalBeta1,4GlcNAc). O-glycosylated. |
| Function | Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane. |
| Protein Name | Neural Cell Adhesion Molecule L1-Like ProteinClose Homolog Of L1 Cleaved Into - Processed Neural Cell Adhesion Molecule L1-Like Protein |
| Database Links | Reactome: R-HSA-447041 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSoluble Forms Produced By Cleavage/Shedding Also ExistProcessed Neural Cell Adhesion Molecule L1-Like Protein: SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Neural Cell Adhesion Molecule L1-Like Protein antibodyAnti-Close Homolog Of L1 Cleaved Into - Processed Neural Cell Adhesion Molecule L1-Like Protein antibodyAnti-CHL1 antibodyAnti-CALL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
