| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CERS2 (55-125) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CERS2 |
| Gene ID: |
29956 |
| Uniprot ID: |
CERS2_HUMAN |
| Immunogen Region: |
55-125 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 55-125 of human CERS2 (NP_071358.1). |
| Immunogen Sequence: |
FFELYVATPLAALLNIKEKT RLRAPPNATLEHFYLTSGKQ PKQVEVELLSRQSGLSGRQV ERWFRRRRNQD |
| Tissue Specificity | Expressed in kidney, liver, brain, heart, placenta and lung. |
| Post Translational Modifications | Acetylated. Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation. Phosphorylated at the C-terminus by CK2, leading to increase the ceramide synthase activity. |
| Function | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions. |
| Protein Name | Ceramide Synthase 2Cers2Lag1 Longevity Assurance Homolog 2Sp260Sphingosine N-Acyltransferase Cers2Tumor Metastasis-Suppressor Gene 1 ProteinVery-Long-Chain Ceramide Synthase Cers2 |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ceramide Synthase 2 antibodyAnti-Cers2 antibodyAnti-Lag1 Longevity Assurance Homolog 2 antibodyAnti-Sp260 antibodyAnti-Sphingosine N-Acyltransferase Cers2 antibodyAnti-Tumor Metastasis-Suppressor Gene 1 Protein antibodyAnti-Very-Long-Chain Ceramide Synthase Cers2 antibodyAnti-CERS2 antibodyAnti-LASS2 antibodyAnti-TMSG1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
