| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CENPH (1-247) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CENPH |
| Gene ID: |
64946 |
| Uniprot ID: |
CENPH_HUMAN |
| Immunogen Region: |
1-247 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-247 of human CENPH (NP_075060.1). |
| Immunogen Sequence: |
MEEQPQMQDADEPADSGGEG RAGGPPQVAGAQAACSEDRM TLLLRLRAQTKQQLLEYKSM VDASEEKTPEQIMQEKQIEA KIEDLENEIEEVKVAFEIKK LALDRMRLSTALKKNLEKIS RQSSVLMDNMKHLLELNKLI MKSQQESWDLEEKLLDIRKK RLQLKQASESKLLEIQTEKN KQKIDLDSMENSERIKIIRQ NLQMEIKITTVIQHVFQNLI LGSKVNWAEDPALKEIVLQ |
| Function | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. |
| Protein Name | Centromere Protein HCenp-HInterphase Centromere Complex Protein 35 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-606279Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreAssociates With Active Centromere-Kinetochore Complexes Throughout The Cell CycleColocalizes With Inner Kinetochore Plate Proteins Cenpa And Cenpc During Both Interphase And Metaphase |
| Alternative Antibody Names | Anti-Centromere Protein H antibodyAnti-Cenp-H antibodyAnti-Interphase Centromere Complex Protein 35 antibodyAnti-CENPH antibodyAnti-ICEN35 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
