| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CDK14 (312-451) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CDK14 |
| Gene ID: |
5218 |
| Uniprot ID: |
CDK14_HUMAN |
| Immunogen Region: |
312-451 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 312-451 of human CDK14 (NP_036527.1). |
| Immunogen Sequence: |
AAFPGMKDIQDQLERIFLVL GTPNEDTWPGVHSLPHFKPE RFTLYSSKNLRQAWNKLSYV NHAEDLASKLLQCSPKNRLS AQAALSHEYFSDLPPRLWEL TDMSSIFTVPNVRLQPEAGE SMRAFGKNNSYGKSLSNSKH |
| Tissue Specificity | Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected. |
| Function | Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. |
| Protein Name | Cyclin-Dependent Kinase 14Cell Division Protein Kinase 14Serine/Threonine-Protein Kinase Pftaire-1Hpftaire1 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmNucleusRecruited To The Cell Membrane By Ccny |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 14 antibodyAnti-Cell Division Protein Kinase 14 antibodyAnti-Serine/Threonine-Protein Kinase Pftaire-1 antibodyAnti-Hpftaire1 antibodyAnti-CDK14 antibodyAnti-KIAA0834 antibodyAnti-PFTK1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and STIM1 knockout (KO) HeLa cells, using [KO Validated] STIM1 Rabbit polyclonal antibody (STJ11100770) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89707/358189/STJ11100770_1__47615.1713122504.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and STIM1 knockout (KO) HeLa cells, using [KO Validated] STIM1 Rabbit polyclonal antibody (STJ11100770) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
