• Western blot analysis of various lysates using CDHR5 Rabbit polyclonal antibody (STJ115789) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-CDHR5 antibody (26-220) (STJ115789)

SKU:
STJ115789

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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CDHR5 (26-220) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CDHR5
Gene ID: 53841
Uniprot ID: CDHR5_HUMAN
Immunogen Region: 26-220
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 26-220 of human CDHR5 (NP_112554.2).
Immunogen Sequence: QAQYCSVNKDIFEVEENTNV TEPLVDIHVPEGQEVTLGAL STPFAFRIQGNQLFLNVTPD YEEKSLLEAQLLCQSGGTLV TQLRVFVSVLDVNDNAPEFP FKTKEIRVEEDTKVNSTVIP ETQLQAEDRDKDDILFYTLQ EMTAGASDYFSLVSVNRPAL RLDRPLDFYERPNMTFWLLV RDTPGENVEPSHTAT
Tissue Specificity Highest expression in kidney, liver, colon and small intestine. In kidney, expressed apically along brush border of proximal convoluted tubule but not in cortical collecting ducts. Isoform 1 is expressed primarily in adult small intestine and colon. Isoform 2 is highly expressed in fetal liver. Expressed in duodenum with higher expression in enterocytes along the villus axis and lower expression in crypts (at protein level).
Post Translational Modifications N- and O-glycosylated.
Function Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation.
Protein Name Cadherin-Related Family Member 5
Mu-Protocadherin
Mucin And Cadherin-Like Protein
Mucin-Like Protocadherin
Mlpcdh
Cellular Localisation Apical Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Microvillus Membrane
Alternative Antibody Names Anti-Cadherin-Related Family Member 5 antibody
Anti-Mu-Protocadherin antibody
Anti-Mucin And Cadherin-Like Protein antibody
Anti-Mucin-Like Protocadherin antibody
Anti-Mlpcdh antibody
Anti-CDHR5 antibody
Anti-MUCDHL antibody
Anti-MUPCDH antibody
Anti-UNQ2781 antibody
Anti-PRO7168 antibody

Information sourced from Uniprot.org

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