| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CDHR5 (26-220) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CDHR5 |
| Gene ID: |
53841 |
| Uniprot ID: |
CDHR5_HUMAN |
| Immunogen Region: |
26-220 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 26-220 of human CDHR5 (NP_112554.2). |
| Immunogen Sequence: |
QAQYCSVNKDIFEVEENTNV TEPLVDIHVPEGQEVTLGAL STPFAFRIQGNQLFLNVTPD YEEKSLLEAQLLCQSGGTLV TQLRVFVSVLDVNDNAPEFP FKTKEIRVEEDTKVNSTVIP ETQLQAEDRDKDDILFYTLQ EMTAGASDYFSLVSVNRPAL RLDRPLDFYERPNMTFWLLV RDTPGENVEPSHTAT |
| Tissue Specificity | Highest expression in kidney, liver, colon and small intestine. In kidney, expressed apically along brush border of proximal convoluted tubule but not in cortical collecting ducts. Isoform 1 is expressed primarily in adult small intestine and colon. Isoform 2 is highly expressed in fetal liver. Expressed in duodenum with higher expression in enterocytes along the villus axis and lower expression in crypts (at protein level). |
| Post Translational Modifications | N- and O-glycosylated. |
| Function | Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. |
| Protein Name | Cadherin-Related Family Member 5Mu-ProtocadherinMucin And Cadherin-Like ProteinMucin-Like ProtocadherinMlpcdh |
| Cellular Localisation | Apical Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionMicrovillus Membrane |
| Alternative Antibody Names | Anti-Cadherin-Related Family Member 5 antibodyAnti-Mu-Protocadherin antibodyAnti-Mucin And Cadherin-Like Protein antibodyAnti-Mucin-Like Protocadherin antibodyAnti-Mlpcdh antibodyAnti-CDHR5 antibodyAnti-MUCDHL antibodyAnti-MUPCDH antibodyAnti-UNQ2781 antibodyAnti-PRO7168 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
