| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:2500-1:20000IF/ICC:1:200-1:800ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
CD53 |
| Gene ID: |
963 |
| Uniprot ID: |
CD53_HUMAN |
| Immunogen Region: |
107-181 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 107-181 of human CD53 (NP_000551.1). |
| Immunogen Sequence: |
EQKLNEYVAKGLTDSIHRYH SDNSTKAAWDSIQSFLQCCG INGTSDWTSGPPASCPSDRK VEGCYAKARLWFHSN |
| Tissue Specificity | B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells. |
| Function | Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Plays a role in the activation of monocytes and B-cells. Acts as an essential regulator of B-cell development by promoting interleukin-7 receptor/IL7R signaling. Promotes also in B-cells the BCR signaling by recruiting PKC to the plasma membrane in order to phosphorylate its substrates. Plays an essential role in B- and T-cells homing to lymph nodes by stabilizing L-selectin/SELL cell surface expression. Mediates also metabolic and inflammatory functions in hepatocytes and adipose tissue by promoting TNF-alpha and LPS signaling independent of the immune compartment. |
| Protein Name | Leukocyte Surface Antigen Cd53Cell Surface Glycoprotein Cd53Tetraspanin-25Tspan-25Cd Antigen Cd53 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneCell JunctionMembraneMulti-Pass Membrane ProteinSynapseConcentrates In Localized Microdomains Along The Plasma Membrane At The Contact Sites Between Cells Of Fused Myotubes |
| Alternative Antibody Names | Anti-Leukocyte Surface Antigen Cd53 antibodyAnti-Cell Surface Glycoprotein Cd53 antibodyAnti-Tetraspanin-25 antibodyAnti-Tspan-25 antibodyAnti-Cd Antigen Cd53 antibodyAnti-CD53 antibodyAnti-MOX44 antibodyAnti-TSPAN25 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
