| Function | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes.when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels. |
| Protein Name | Atypical Chemokine Receptor 1Duffy Antigen/Chemokine ReceptorFy GlycoproteinGpfyGlycoprotein DPlasmodium Vivax ReceptorCd Antigen Cd234 |
| Database Links | Reactome: R-HSA-375276 |
| Cellular Localisation | Early EndosomeRecycling EndosomeMembraneMulti-Pass Membrane ProteinPredominantly Localizes To Endocytic VesiclesAnd Upon Stimulation By The Ligand Is Internalized Via CaveolaeOnce InternalizedThe Ligand Dissociates From The ReceptorAnd Is Targeted To Degradation While The Receptor Is Recycled Back To The Cell Membrane |
| Alternative Antibody Names | Anti-Atypical Chemokine Receptor 1 antibodyAnti-Duffy Antigen/Chemokine Receptor antibodyAnti-Fy Glycoprotein antibodyAnti-Gpfy antibodyAnti-Glycoprotein D antibodyAnti-Plasmodium Vivax Receptor antibodyAnti-Cd Antigen Cd234 antibodyAnti-ACKR1 antibodyAnti-DARC antibodyAnti-FY antibodyAnti-GPD antibody |
Information sourced from Uniprot.org
