• Immunohistochemistry analysis of Langerin/CD207 in paraffin-embedded Human skin tissue using Langerin/CD207 Rabbit polyclonal antibody (STJ11105660) at a dilution of 1:1000 (40x lens). High pressure antigen retrieval was performed with 0. 01 M Tris-EDTA buffer (pH 9. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of Langerin/CD207 in paraffin-embedded Human tonsil tissue using Langerin/CD207 Rabbit polyclonal antibody (STJ11105660) at a dilution of 1:1000 (40x lens). High pressure antigen retrieval was performed with 0. 01 M Tris-EDTA buffer (pH 9. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of Langerin/CD207 in paraffin-embedded Human esophagus tissue using Langerin/CD207 Rabbit polyclonal antibody (STJ11105660) at a dilution of 1:1000 (40x lens). High pressure antigen retrieval was performed with 0. 01 M Tris-EDTA buffer (pH 9. 0) prior to immunohistochemistry staining.

Anti-CD207 antibody (65-328) (STJ11105660)

SKU:
STJ11105660

£112.50 - £522.50
Current Stock:
Host: Rabbit
Applications: IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-C-Type Lectin Domain Family 4 Member K (65-328) is suitable for use in Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC-P 1:50 0-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CD207
Gene ID: 50489
Uniprot ID: CLC4K_HUMAN
Immunogen Region: 65-328
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 65-328 of human Langerin/CD207 (NP_056532.4).
Immunogen Sequence: PRFMGTISDVKTNVQLLKGR VDNISTLDSEIKKNSDGMEA AGVQIQMVNESLGYVRSQFL KLKTSVEKANAQIQILTRSW EEVSTLNAQIPELKSDLEKA SALNTKIRALQGSLENMSKL LKRQNDILQVVSQGWKYFKG NFYYFSLIPKTWYSAEQFCV SRNSHLTSVTSESEQEFLYK TAGGLIYWIGLTKAGMEGDW SWVDDTPFNKVQSVRFWIPG EPNNAGNNEHCGNIKAPSL
Tissue Specificity Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
Function Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs).is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
Protein Name C-Type Lectin Domain Family 4 Member K
Langerin
Cd Antigen Cd207
Database Links Reactome: R-HSA-1236978
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Found In Birbeck Granules (Bgs)
Which Are Organelles Consisting Of Superimposed And Zippered Membranes
Alternative Antibody Names Anti-C-Type Lectin Domain Family 4 Member K antibody
Anti-Langerin antibody
Anti-Cd Antigen Cd207 antibody
Anti-CD207 antibody
Anti-CLEC4K antibody

Information sourced from Uniprot.org

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