| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CD180 |
| Gene ID: | 4064 |
| Uniprot ID: | CD180_HUMAN |
| Immunogen Region: | 24-220 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-220 of human CD180 (NP_005573.2). |
| Immunogen Sequence: | WDQMCIEKEANKTYNCENLG LSEIPDTLPNTTEFLEFSFN FLPTIHNRTFSRLMNLTFLD LTRCQINWIHEDTFQSHHQL STLVLTGNPLIFMAETSLNG PKSLKHLFLIQTGISNLEFI PVHNLENLESLYLGSNHISS IKFPKDFPARNLKVLDFQNN AIHYISREDMRSLEQAINLS LNFNGNNVKGIELGAFD |
| Tissue Specificity | Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells. |
| Function | May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells. |
| Protein Name | Cd180 AntigenLymphocyte Antigen 64Radioprotective 105 Kda ProteinCd Antigen Cd180 |
| Database Links | Reactome: R-HSA-166016 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Cd180 Antigen antibodyAnti-Lymphocyte Antigen 64 antibodyAnti-Radioprotective 105 Kda Protein antibodyAnti-Cd Antigen Cd180 antibodyAnti-CD180 antibodyAnti-LY64 antibodyAnti-RP105 antibody |
Information sourced from Uniprot.org