Anti-CD10 antibody [FR4D11] (STJ16101083)


Current Stock:
Host: Mouse
Applications: FC, IF, IHC
Reactivity: Human
Short Description: Mouse monoclonal antibody anti-CD10 is suitable for use in Flow Cytometry, Immunofluorescence and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: FR4D11
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: PBS with 0.02% Sodium Azide
Purification: Affinity purified from tissue culture.
Concentration: Available as 0.1 mg/mL, 0.5 mg/mL or 1mg/mL. Please check against pricing options.
Dilution Range: Flow cytometry (0.5-1.0 µg/million cells in 0.1 ml). Immunofluorescence (0.5-1.0 µg/ml). Immunohistology (1-2 µg/ml for 30 min at RT; an appropriate antigen retrieval method for staining of formalin-fixed tissues has not been established to date).
Storage Instruction: Store at 2-8°C upon receipt.
Immunogen: A BALB/c mice was immunized with Raji cells. NA NA NA NA Fusion partner: X63-Ag8.653. NA NA NA NA
Background FR4D11 reacts with high affinity to CD10 or CALLA, a cell surface enzyme with neutral metalloendopeptidase activity, inactivating a variety of biologically active peptides. CD10 is a 100 kDa glycoprotein, expressed on 70% of pre-B ALL-cells (common ALL) , but also on early lymphoid progenitor-cells in bone marrow and fetal liver. Other normal CD10 positive tissues include renal epithelium, fibroblasts and germinal centre B-cells. Density of CD10 antigen has been shown to be related to cell differentiation and may have prognostic value for B-cell lineage acute leukemia. CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells.

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12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance