| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CAV2 |
| Gene ID: | 858 |
| Uniprot ID: | CAV2_HUMAN |
| Immunogen Region: | 1-65 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-65 of human CAV2 (NP_001224.1). |
| Immunogen Sequence: | MGLETEKADVQLFMDDDSYS HHSGLEYADPEKFADSDQDR DPHRLNSHLKLGFEDVIAEP VTTHS |
| Tissue Specificity | Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts. |
| Post Translational Modifications | Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells. Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin. |
| Function | May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression. |
| Protein Name | Caveolin-2 |
| Database Links | Reactome: R-HSA-9009391 |
| Cellular Localisation | Nucleus Cytoplasm Golgi Apparatus Membrane Peripheral Membrane Protein Cell Membrane Membrane Caveola Potential Hairpin-Like Structure In The Membrane Membrane Protein Of Caveolae Tyr-19-Phosphorylated Form Is Enriched At Sites Of Cell-Cell Contact And Is Translocated To The Nucleus In Complex With Mapk1 In Response To Insulin Tyr-27-Phosphorylated Form Is Located Both In The Cytoplasm And Plasma Membrane Cav1-Mediated Ser-23-Phosphorylated Form Locates To The Plasma Membrane Ser-36-Phosphorylated Form Resides In Intracellular Compartments |
| Alternative Antibody Names | Anti-Caveolin-2 antibody Anti-CAV2 antibody |
Information sourced from Uniprot.org