| Post Translational Modifications | (Microbial infection) Cleaved by S.pyogenes SpeB protease.leading to its degradation. Degradation by SpeB prevents autophagy, promoting to S.pyogenes intracellular replication. |
| Function | Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy. Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation. Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C. May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion. |
| Protein Name | Calcium-Binding And Coiled-Coil Domain-Containing Protein 2Antigen Nuclear Dot 52 Kda ProteinNuclear Domain 10 Protein Ndp52Nuclear Domain 10 Protein 52Nuclear Dot Protein 52 |
| Cellular Localisation | CytoplasmPerinuclear RegionCytoskeletonCytoplasmic VesicleAutophagosome MembranePeripheral Membrane ProteinLocalizes To Nuclear DotsIt Is Not A Nuclear Dot-Associated Protein But Localizes Predominantly In The Cytoplasm With A Coarse-Grained Distribution Preferentially Close To The Nucleus |
| Alternative Antibody Names | Anti-Calcium-Binding And Coiled-Coil Domain-Containing Protein 2 antibodyAnti-Antigen Nuclear Dot 52 Kda Protein antibodyAnti-Nuclear Domain 10 Protein Ndp52 antibodyAnti-Nuclear Domain 10 Protein 52 antibodyAnti-Nuclear Dot Protein 52 antibodyAnti-CALCOCO2 antibodyAnti-NDP52 antibody |
Information sourced from Uniprot.org
