| Post Translational Modifications | Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small a small peptide agonist. Sulfation at Tyr-14 is important for CHIPS binding. Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to the ligand. The key residues involved in this process are Ser-334 and Ser-338. |
| Function | Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. |
| Protein Name | C5a Anaphylatoxin Chemotactic Receptor 1C5a Anaphylatoxin Chemotactic ReceptorC5a-RC5arCd Antigen Cd88 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594Reactome: R-HSA-6798695Reactome: R-HSA-977606 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmic VesiclePhosphorylated C5ar Colocalizes With Arrb1 And Arrb2 In Cytoplasmic Vesicles |
| Alternative Antibody Names | Anti-C5a Anaphylatoxin Chemotactic Receptor 1 antibodyAnti-C5a Anaphylatoxin Chemotactic Receptor antibodyAnti-C5a-R antibodyAnti-C5ar antibodyAnti-Cd Antigen Cd88 antibodyAnti-C5AR1 antibodyAnti-C5AR antibodyAnti-C5R1 antibody |
Information sourced from Uniprot.org
